Seroatlas · Human Serome Atlas

SNX29

Sorting nexin-29

Also known as: FLJ12363, RUNDC2A, SNX29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TEQ0
Gene
SNX29
Ensembl
ENSG00000048471
Chromosome
16
Canonical length
813 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

813 residues, UniProt reviewed canonical sequence.

>Q8TEQ0|SNX29
     1  MSGSQNNDKR QFLLERLLDA VKQCQIRFGG RKEIASDSDS RVTCLCAQFE AVLQHGLKRS
    61  RGLALTAAAI KQAAGFASKT ETEPVFWYYV KEVLNKHELQ RFYSLRHIAS DVGRGRAWLR
   121  CALNEHSLER YLHMLLADRC RLSTFYEDWS FVMDEERSSM LPTMAAGLNS ILFAINIDNK
   181  DLNGQSKFAP TVSDLLKEST QNVTSLLKES TQGVSSLFRE ITASSAVSIL IKPEQETDPL
   241  PVVSRNVSAD AKCKKERKKK KKVTNIISFD DEEDEQNSGD VFKKTPGAGE SSEDNSDRSS
   301  VNIMSAFESP FGPNSNGSQS SNSWKIDSLS LNGEFGYQKL DVKSIDDEDV DENEDDVYGN
   361  SSGRKHRGHS ESPEKPLEGN TCLSQMHSWA PLKVLHNDSD ILFPVSGVGS YSPADAPLGS
   421  LENGTGPEDH VLPDPGLRYS VEASSPGHGS PLSSLLPSAS VPESMTISEL RQATVAMMNR
   481  KDELEEENRS LRNLLDGEME HSAALRQEVD TLKRKVAEQE ERQGMKVQAL ARENEVLKVQ
   541  LKKYVGAVQM LKREGQTAEV PNLWSVDGEV TVAEQKPGEI AEELASSYER KLIEVAEMHG
   601  ELIEFNERLH RALVAKEALV SQMRQELIDL RGPVPGDLSQ TSEDQSLSDF EISNRALINV
   661  WIPSVFLRGK AANAFHVYQV YIRIKDDEWN IYRRYTEFRS LHHKLQNKYP QVRAYNFPPK
   721  KAIGNKDAKF VEERRKQLQN YLRSVMNKVI QMVPEFAASP KKETLIQLMP FFVDITPPGE
   781  PVNSRPKAAS RFPKLSRGQP RETRNVEPQS GDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • retina: 22 nTPM
  • parathyroid gland: 21 nTPM
  • thymus: 20 nTPM
  • kidney: 18 nTPM
  • tonsil: 15 nTPM
  • lymph node: 12 nTPM

Single-cell type

  • cone photoreceptor cells: 2,109 nCPM
  • proximal tubule cells: 1,412 nCPM
  • rod photoreceptor cells: 1,228 nCPM
  • distal convoluted tubule cells: 1,155 nCPM
  • renal connecting tubule cells: 1,054 nCPM
  • somatotrophs: 846 nCPM

Immune cell

  • naive B-cell: 22 nTPM
  • memory B-cell: 11 nTPM
  • plasmacytoid DC: 7.4 nTPM
  • classical monocyte: 6.9 nTPM
  • naive CD4 T-cell: 5.2 nTPM
  • intermediate monocyte: 4.5 nTPM

Brain region

  • white matter: 65 nTPM
  • basal ganglia: 51 nTPM
  • pons: 49 nTPM
  • thalamus: 49 nTPM
  • medulla oblongata: 48 nTPM
  • midbrain: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
-1.79
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX29 as an antibody target. Whether an autoantibody or antibody against SNX29 could matter depends on whether native SNX29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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