Seroatlas · Human Serome Atlas

SNX25

Sorting nexin-25

Also known as: SBBI31, SNX25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3E2
Gene: SNX25
Ensembl: ENSG00000109762
Chromosome: 4
Canonical length: 840 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity and type I transforming growth factor beta receptor binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway and receptor catabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

840 residues, UniProt reviewed canonical sequence.

>Q9H3E2|SNX25
     1  MDKALKEVFD YSYRDYILSW YGNLSRDEGQ LYHLLLEDFW EIARQLHHRL SHVDVVKVVC
    61  NDVVRTLLTH FCDLKAANAR HEEQPRPFVL HACLRNSDDE VRFLQTCSRV LVFCLLPSKD
   121  VQSLSLRIML AEILTTKVLK PVVELLSNPD YINQMLLAQL AYREQMNEHH KRAYTYAPSY
   181  EDFIKLINSN SDVEFLKQLR YQIVVEIIQA TTISSFPQLK RHKGKETAAM KADLLRARNM
   241  KRYINQLTVA KKQCEKRIRI LGGPAYDQQE DGALDEGEGP QSQKILQFED ILANTFYREH
   301  FGMYMERMDK RALISFWESV EHLKNANKNE IPQLVGEIYQ NFFVESKEIS VEKSLYKEIQ
   361  QCLVGNKGIE VFYKIQEDVY ETLKDRYYPS FIVSDLYEKL LIKEEEKHAS QMISNKDEMG
   421  PRDEAGEEAV DDGTNQINEQ ASFAVNKLRE LNEKLEYKRQ ALNSIQNAPK PDKKIVSKLK
   481  DEIILIEKER TDLQLHMART DWWCENLGMW KASITSGEVT EENGEQLPCY FVMVSLQEVG
   541  GVETKNWTVP RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDQKF MEKSKNQLNK
   601  FLQNLLSDER LCQSEALYAF LSPSPDYLKV IDVQGKKNSF SLSSFLERLP RDFFSHQEEE
   661  TEEDSDLSDY GDDVDGRKDA LAEPCFMLIG EIFELRGMFK WVRRTLIALV QVTFGRTINK
   721  QIRDTVSWIF SEQMLVYYIN IFRDAFWPNG KLAPPTTIRS KEQSQETKQR AQQKLLENIP
   781  DMLQSLVGQQ NARHGIIKIF NALQETRANK HLLYALMELL LIELCPELRV HLDQLKAGQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

lung: 27 nTPM
retina: 24 nTPM
choroid plexus: 22 nTPM
cerebellum: 18 nTPM
thyroid gland: 16 nTPM
blood vessel: 15 nTPM

Single-cell type

alveolar cells type 2: 1,115 nCPM
podocytes: 793 nCPM
transitional alveolar cells: 532 nCPM
pituicytes/fscs: 414 nCPM
alveolar cells type 1: 403 nCPM
melanocytes: 360 nCPM

Immune cell

naive B-cell: 1 nTPM
memory B-cell: 0.7 nTPM
memory CD8 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

choroid plexus: 52 nTPM
cerebellum: 37 nTPM
midbrain: 22 nTPM
medulla oblongata: 22 nTPM
pons: 21 nTPM
hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX25 as an antibody target. Whether an autoantibody or antibody against SNX25 could matter depends on whether native SNX25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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