Seroatlas · Human Serome Atlas

SNX22

Sorting nexin-22

Also known as: FLJ13952, SNX22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96L94
Gene: SNX22
Ensembl: ENSG00000157734
Chromosome: 15
Canonical length: 193 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q96L94|SNX22
     1  MLEVHIPSVG PEAEGPRQSP EKSHMVFRVE VLCSGRRHTV PRRYSEFHAL HKRIKKLYKV
    61  PDFPSKRLPN WRTRGLEQRR QGLEAYIQGI LYLNQEVPKE LLEFLRLRHF PTDPKASNWG
   121  TLREFLPGDS SSQQHQRPVL SFHVDPYVCN PSPESLPNVV VNGVLQGLYS FSISPDKAQP
   181  KAACHPAPLP PMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 36 nTPM
spinal cord: 28 nTPM
midbrain: 22 nTPM
hippocampal formation: 21 nTPM
amygdala: 18 nTPM
hypothalamus: 14 nTPM

Single-cell type

oligodendrocyte progenitor cells: 139 nCPM
epicardial cells: 98 nCPM
alveolar cells type 1: 81 nCPM
cardiomyocytes: 52 nCPM
oligodendrocytes: 43 nCPM
b-cells: 33 nCPM

Immune cell

naive B-cell: 6.1 nTPM
memory B-cell: 3.3 nTPM
total PBMC: 1.4 nTPM
myeloid DC: 1 nTPM
basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM

Brain region

medulla oblongata: 28 nTPM
white matter: 24 nTPM
spinal cord: 22 nTPM
pons: 21 nTPM
midbrain: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX22 as an antibody target. Whether an autoantibody or antibody against SNX22 could matter depends on whether native SNX22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...