Seroatlas · Human Serome Atlas

SNX16

Sorting nexin-16

Also known as: SNX16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57768
Gene
SNX16
Ensembl
ENSG00000104497
Chromosome
8
Canonical length
344 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>P57768|SNX16
     1  MATPYVPVPM PIGNSASSFT TNRNQRSSSF GSVSTSSNSS KGQLEDSNMG NFKQTSVPDQ
    61  MDNTSSVCSS PLIRTKFTGT ASSIEYSTRP RDTEEQNPET VNWEDRPSTP TILGYEVMEE
   121  RAKFTVYKIL VKKTPEESWV VFRRYTDFSR LNDKLKEMFP GFRLALPPKR WFKDNYNADF
   181  LEDRQLGLQA FLQNLVAHKD IANCLAVREF LCLDDPPGPF DSLEESRAFC ETLEETNYRL
   241  QKELLEKQKE MESLKKLLSE KQLHIDTLEN RIRTLSLEPE ESLDVSETEG EQILKVESSA
   301  LEVDQDVLDE ESRADNKPCL SFSEPENAVS EIEVAEVAYD AEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 16 nTPM
  • testis: 14 nTPM
  • spleen: 11 nTPM
  • smooth muscle: 11 nTPM
  • skin: 11 nTPM
  • gallbladder: 10 nTPM

Single-cell type

  • esophageal apical cells: 248 nCPM
  • late spermatids: 220 nCPM
  • late primary spermatocytes: 90 nCPM
  • early primary spermatocytes: 87 nCPM
  • early spermatids: 81 nCPM
  • ocular epithelial cells: 48 nCPM

Immune cell

  • basophil: 9.2 nTPM
  • neutrophil: 6.2 nTPM
  • eosinophil: 6.1 nTPM
  • T-reg: 4.9 nTPM
  • classical monocyte: 4.4 nTPM
  • naive B-cell: 4.4 nTPM

Brain region

  • pons: 20 nTPM
  • midbrain: 18 nTPM
  • hypothalamus: 16 nTPM
  • white matter: 16 nTPM
  • cerebellum: 16 nTPM
  • medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
0.99
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX16 as an antibody target. Whether an autoantibody or antibody against SNX16 could matter depends on whether native SNX16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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