Seroatlas · Human Serome Atlas

SNX14

Sorting nexin-14

Also known as: RGS-PX2, SNX14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5W7
Gene
SNX14
Ensembl
ENSG00000135317
Chromosome
6
Canonical length
946 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

946 residues, UniProt reviewed canonical sequence.

>Q9Y5W7|SNX14
     1  MVPWVRTMGQ KLKQRLRLDV GREICRQYPL FCFLLLCLSA ASLLLNRYIH ILMIFWSFVA
    61  GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGHS CAVCGKVKCK RHRPSLLLEN
   121  YQPWLDLKIS SKVDASLSEV LELVLENFVY PWYRDVTDDE SFVDELRITL RFFASVLIRR
   181  IHKVDIPSII TKKLLKAAMK HIEVIVKARQ KVKNTEFLQQ AALEEYGPEL HVALRSRRDE
   241  LHYLRKLTEL LFPYILPPKA TDCRSLTLLI REILSGSVFL PSLDFLADPD TVNHLLIIFI
   301  DDSPPEKATE PASPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKQEGAV
   361  HVLQFCLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESIDKIR FDPFIVEEIQ
   421  RIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRQLLR GAESPTRNSK
   481  LNRGSLSLDD FRNTQKRGES FGISRIGSKI KGVFKSTTME GAMLPNYGVA EGEDDFIEEG
   541  IVVMEDDSPV EAVSTPNTPR NLAAWKISIP YVDFFEDPSS ERKEKKERIP VFCIDVERND
   601  RRAVGHEPEH WSVYRRYLEF YVLESKLTEF HGAFPDAQLP SKRIIGPKNY EFLKSKREEF
   661  QEYLQKLLQH PELSNSQLLA DFLSPNGGET QFLDKILPDV NLGKIIKSVP GKLMKEKGQH
   721  LEPFIMNFIN SCESPKPKPS RPELTILSPT SENNKKLFND LFKNNANRAE NTERKQNQNY
   781  FMEVMTVEGV YDYLMYVGRV VFQVPDWLHH LLMGTRILFK NTLEMYTDYY LQCKLEQLFQ
   841  EHRLVSLITL LRDAIFCENT EPRSLQDKQK GAKQTFEEMM NYIPDLLVKC IGEETKYESI
   901  RLLFDGLQQP VLNKQLTYVL LDIVIQELFP ELNKVQKEVT SVTSWM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • testis: 46 nTPM
  • liver: 27 nTPM
  • hypothalamus: 21 nTPM
  • parathyroid gland: 20 nTPM
  • adrenal gland: 20 nTPM
  • cerebral cortex: 20 nTPM

Single-cell type

  • choroid plexus epithelial cells: 200 nCPM
  • ependymal cells: 158 nCPM
  • microglia: 157 nCPM
  • brain excitatory neurons: 156 nCPM
  • brain inhibitory neurons: 152 nCPM
  • other brain neurons: 151 nCPM

Immune cell

  • eosinophil: 19 nTPM
  • basophil: 14 nTPM
  • non-classical monocyte: 12 nTPM
  • intermediate monocyte: 8.5 nTPM
  • myeloid DC: 3.6 nTPM
  • NK-cell: 3.2 nTPM

Brain region

  • choroid plexus: 4.7 nTPM
  • pons: 4.5 nTPM
  • hypothalamus: 4.4 nTPM
  • midbrain: 4.2 nTPM
  • cerebellum: 4 nTPM
  • medulla oblongata: 3.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNX14.

Disease | AllUniProt

Conditions SNX14 is implicated in, by any mechanism.

  • Spinocerebellar ataxia, autosomal recessive, 20 (SCAR20) MIM:616354

Disease | GeneticClinVar

46 pathogenic / likely-pathogenic of 421 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
1.85
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX14 as an antibody target. Whether an autoantibody or antibody against SNX14 could matter depends on whether native SNX14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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