Seroatlas · Human Serome Atlas

SNX13

Sorting nexin-13

Also known as: KIAA0713, RGS-PX1, SNX13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5W8
Gene
SNX13
Ensembl
ENSG00000071189
Chromosome
7
Canonical length
968 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

968 residues, UniProt reviewed canonical sequence.

>Q9Y5W8|SNX13
     1  MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF GKTNSEKYLE
    61  QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII DEPLQQVIQF SLRDYVQYWY
   121  YTLSDDESFL LEIRQTLQNA LIQFATRSKE IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT
   181  EKDDQVKGTA EDLVDTFFEV EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD
   241  FQNKIMRYFV REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI
   301  GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR LQSGKEINTV
   361  KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL FFWMTVEGYR VTAQQQLEVL
   421  LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL SEKASPRVTV DDYLVAKLAD TLNHEDPTPE
   481  IFDDIQRKVY ELMLRDERFY PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT
   541  GSINLSLDDL SNVSSDDSVQ LHAYISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN
   601  LNSEEMWKTY RRYSDFHDFH MRITEQFESL SSILKLPGKK TFNNMDRDFL EKRKKDLNAY
   661  LQLLLAPEMM KASPALAHYV YDFLENKAYS KGKGDFARKM DTFVNPLRNS MRNVSNAVKS
   721  LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS FFKVPPLIPK TDSDPEHRRV SAQLDDNVDD
   781  NIPLRVMLLL MDEVFDLKER NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ
   841  VADSVKRFRD AFWPNGILAE AVPCRDKSIR MRTRVAGKTK LLAIMPDELK HIIGAETTRK
   901  GILRVFEMFQ HNQLNRRMVY VFLEGFLETL FPQYKFRELF NKLHSRSKQM QKYKQKLQTT
   961  QAPSLQKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 20 nTPM
  • thyroid gland: 16 nTPM
  • tongue: 16 nTPM
  • skeletal muscle: 14 nTPM
  • placenta: 13 nTPM
  • rectum: 13 nTPM

Single-cell type

  • early spermatids: 476 nCPM
  • late spermatids: 407 nCPM
  • neutrophils: 355 nCPM
  • microglia: 311 nCPM
  • neutrophil progenitors: 304 nCPM
  • gonadotrophs: 209 nCPM

Immune cell

  • neutrophil: 2 nTPM
  • intermediate monocyte: 1.5 nTPM
  • eosinophil: 1.2 nTPM
  • non-classical monocyte: 1.2 nTPM
  • MAIT T-cell: 1.1 nTPM
  • basophil: 0.9 nTPM

Brain region

  • cerebellum: 21 nTPM
  • hypothalamus: 20 nTPM
  • midbrain: 20 nTPM
  • cerebral cortex: 19 nTPM
  • medulla oblongata: 19 nTPM
  • thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.4
gnomAD missense Z
1.99
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX13 as an antibody target. Whether an autoantibody or antibody against SNX13 could matter depends on whether native SNX13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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