SNX12
Sorting nexin-12
Also known as: SNX12_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UMY4
- Gene
- SNX12
- Ensembl
- ENSG00000147164
- Chromosome
- X
- Canonical length
- 162 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Canonical amino-acid sequenceUniProt
162 residues, UniProt reviewed canonical sequence.
>Q9UMY4|SNX12
1 MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY EVRMRTNLPI
61 FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR
121 QGLEQFINKI AGHPLAQNER CLHMFLQEEA IDRNYVPGKV RQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SNX12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 56 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 56 nTPM
- tongue: 48 nTPM
- esophagus: 47 nTPM
- skeletal muscle: 42 nTPM
- seminal vesicle: 41 nTPM
- skin: 41 nTPM
Single-cell type
- esophageal apical cells: 69 nCPM
- esophageal suprabasal cells: 66 nCPM
- cytotrophoblasts: 60 nCPM
- enterocytes: 58 nCPM
- oocytes: 46 nCPM
- migrating cytotrophoblasts: 45 nCPM
Immune cell
- basophil: 6.9 nTPM
- eosinophil: 4.9 nTPM
- T-reg: 4.7 nTPM
- intermediate monocyte: 4.2 nTPM
- memory B-cell: 4.2 nTPM
- naive CD8 T-cell: 3.5 nTPM
Brain region
- thalamus: 71 nTPM
- hypothalamus: 69 nTPM
- midbrain: 67 nTPM
- spinal cord: 64 nTPM
- basal ganglia: 64 nTPM
- pons: 63 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0.78
- gnomAD missense Z
- 2.16
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- endocytic recycling
- late endosome to Golgi transport
- negative regulation of early endosome to late endosome transport
- negative regulation of gene expression
- negative regulation of protein catabolic process
- negative regulation of protein processing
- negative regulation of protein transport
- protein transport
- regulation of endocytosis
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SNX12 as an antibody target. Whether an autoantibody or antibody against SNX12 could matter depends on whether native SNX12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SNX12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SNX12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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