Seroatlas · Human Serome Atlas

SNX11

Sorting nexin-11

Also known as: SNX11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5W9
Gene: SNX11
Ensembl: ENSG00000002919
Chromosome: 17
Canonical length: 270 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q9Y5W9|SNX11
     1  MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT AKTSCVRRRY
    61  REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR QGLQHFLEKV LQSVVLLSDS
   121  QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA ILRYAMSNCG WAQEERQSSS HLAKGDQPKS
   181  CCFLPRSGRR SSPSPPPSEE KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG
   241  TSTLQSVRRA VGGDHAVPLD PGQLETVLEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

tonsil: 27 nTPM
spleen: 21 nTPM
bone marrow: 20 nTPM
lymph node: 20 nTPM
thyroid gland: 19 nTPM
esophagus: 18 nTPM

Single-cell type

oocytes: 65 nCPM
esophageal apical cells: 51 nCPM
neutrophils: 44 nCPM
kupffer cells: 42 nCPM
hofbauer cells: 31 nCPM
differentiating spermatogonia: 27 nCPM

Immune cell

neutrophil: 93 nTPM
non-classical monocyte: 55 nTPM
intermediate monocyte: 43 nTPM
eosinophil: 36 nTPM
classical monocyte: 35 nTPM
basophil: 29 nTPM

Brain region

white matter: 21 nTPM
medulla oblongata: 20 nTPM
spinal cord: 20 nTPM
thalamus: 20 nTPM
midbrain: 18 nTPM
basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol phosphate binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRPV3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX11 as an antibody target. Whether an autoantibody or antibody against SNX11 could matter depends on whether native SNX11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX11 is annotated at the cell surface, where native SNX11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNX11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...