Seroatlas · Human Serome Atlas

SNURF

SNRPN upstream reading frame protein

Also known as: SNURF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y675
Gene: SNURF
Ensembl: ENSG00000273173
Chromosome: 15
Canonical length: 71 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

This gene is located within the Prader-Willi Syndrome critical region on chromosome 15. Transcripts produced from this gene initiate at an imprinting center and are paternally-imprinted. These transcripts may be bicistronic and also encode SNRPN (small nuclear ribonucleoprotein polypeptide N) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. Extensive alternative splicing and promoter usage occurs in this region and the full-length nature of some of these transcripts has not been determined. Alterations in the imprinting center are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

71 residues, UniProt reviewed canonical sequence.

>Q9Y675|SNURF
     1  MERARDRLHL RRTTEQHVPE VEVQVKRRRT ASLSNQECQL YPRRSQQQQV PVVDFQAELR
    61  QAFLAETPRG G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNURF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 90 nTPM
skeletal muscle: 58 nTPM
cerebellum: 40 nTPM
heart muscle: 30 nTPM
epididymis: 25 nTPM
retina: 22 nTPM

Single-cell type

epididymal principal cells: 31 nCPM
epididymal efferent duct absorptive cells: 5.3 nCPM
epididymal basal cells: 5.1 nCPM
epididymal clear cells: 4.1 nCPM
paneth cells: 3.9 nCPM
gastric chief cells: 3.3 nCPM

Immune cell

naive CD4 T-cell: 41 nTPM
naive CD8 T-cell: 38 nTPM
T-reg: 36 nTPM
memory CD4 T-cell: 33 nTPM
MAIT T-cell: 31 nTPM
naive B-cell: 28 nTPM

Brain region

cerebellum: 38 nTPM
cerebral cortex: 34 nTPM
hypothalamus: 28 nTPM
white matter: 21 nTPM
hippocampal formation: 21 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.46
gnomAD missense Z: 0.3
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

ATPase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNURF as an antibody target. Whether an autoantibody or antibody against SNURF could matter depends on whether native SNURF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNURF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNURF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...