Seroatlas · Human Serome Atlas

SNTN

Sentan

Also known as: FLJ44379, S100AL, SNTAN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NMZ2
Gene
SNTN
Ensembl
ENSG00000188817
Chromosome
3
Canonical length
147 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>A6NMZ2|SNTN
     1  MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI
    61  ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF
   121  EDFMILLLSI TVMSDLLQNI RNVKIMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
163 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 163 nTPM
  • thyroid gland: 17 nTPM
  • lung: 13 nTPM
  • cervix: 2.9 nTPM
  • endometrium: 2.7 nTPM
  • skin: 1.1 nTPM

Single-cell type

  • fallopian tube ciliated cells: 1,140 nCPM
  • respiratory ciliated cells: 991 nCPM
  • epididymal efferent duct ciliated cells: 647 nCPM
  • endometrial ciliated cells: 547 nCPM
  • parietal cells: 12 nCPM
  • ependymal cells: 9.5 nCPM

Immune cell

  • basophil: 1 nTPM
  • neutrophil: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • cerebellum: 18 nTPM
  • cerebral cortex: 13 nTPM
  • medulla oblongata: 12 nTPM
  • white matter: 12 nTPM
  • midbrain: 11 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNTN as an antibody target. Whether an autoantibody or antibody against SNTN could matter depends on whether native SNTN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNTN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNTN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNTN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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