Seroatlas · Human Serome Atlas

SNPH

Syntaphilin

Also known as: bA314N13.5, SNPH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15079
Gene
SNPH
Ensembl
ENSG00000101298
Chromosome
20
Canonical length
494 aa
Protein class
Predicted membrane proteins
Subcellular location
Cytokinetic bridge,Mitochondria

OverviewNCBI Gene

Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>O15079|SNPH
     1  MAMSLPGSRR TSAGSRRRTS PPVSVRDAYG TSSLSSSSNS GSYKGSDSSP TPRRSMKYTL
    61  CSDNHGIKPP TPEQYLTPLQ QKEVCIRHLK ARLKDTQDRL QDRDTEIDDL KTQLSRMQED
   121  WIEEECHRVE AQLALKEARK EIKQLKQVID TVKNNLIDKD KGLQKYFVDI NIQNKKLETL
   181  LHSMEVAQNG MAKEDGTGES AGGSPARSLT RSSTYTKLSD PAVCGDRQPG DPSSGSAEDG
   241  ADSGFAAADD TLSRTDALEA SSLLSSGVDC GTEETSLHSS FGLGPRFPAS NTYEKLLCGM
   301  EAGVQASCMQ ERAIQTDFVQ YQPDLDTILE KVTQAQVCGT DPESGDRCPE LDAHPSGPRD
   361  PNSAVVVTVG DELEAPEPIT RGPTPQRPGA NPNPGQSVSV VCPMEEEEEA AVAEKEPKSY
   421  WSRHYIVDLL AVVVPAVPTV AWLCRSQRRQ GQPIYNISSL LRGCCTVALH SIRRISCRSL
   481  SQPSPSPAGG GSQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNPH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 73 nTPM
  • hippocampal formation: 61 nTPM
  • amygdala: 58 nTPM
  • basal ganglia: 46 nTPM
  • hypothalamus: 31 nTPM
  • cerebellum: 30 nTPM

Single-cell type

  • brain inhibitory neurons: 24 nCPM
  • astrocytes: 21 nCPM
  • brain excitatory neurons: 21 nCPM
  • oligodendrocyte progenitor cells: 21 nCPM
  • retinal horizontal cells: 20 nCPM
  • other brain neurons: 20 nCPM

Immune cell

  • naive CD4 T-cell: 1 nTPM
  • naive CD8 T-cell: 1 nTPM
  • gdT-cell: 0.5 nTPM
  • total PBMC: 0.5 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM

Brain region

  • cerebral cortex: 188 nTPM
  • hippocampal formation: 146 nTPM
  • amygdala: 130 nTPM
  • white matter: 121 nTPM
  • basal ganglia: 112 nTPM
  • pons: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
1.51
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNPH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNPH as an antibody target. Whether an autoantibody or antibody against SNPH could matter depends on whether native SNPH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNPH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNPH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNPH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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