SNORC
Protein SNORC
Also known as: ASCL830, C2orf82, SNORC_HUMAN, UNQ830
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UX34
- Gene
- SNORC
- Ensembl
- ENSG00000182600
- Chromosome
- 2
- Canonical length
- 121 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Nucleoli
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to be involved in cartilage development. Predicted to be located in several cellular components, including collagen-containing extracellular matrix; cytoplasm; and extracellular region. Predicted to be active in cell periphery. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
121 residues, UniProt reviewed canonical sequence.
>Q6UX34|SNORC
1 MASCLALRMA LLLVSGVLAP AVLTDDVPQE PVPTLWNEPA ELPSGEGPVE STSPGREPVD
61 TGPPAPTVAP GPEDSTAQER LDQGGGSLGP GAIAAIVIAA LLATCVVLAL VVVALRKFSA
121 SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SNORC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 88 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 88 nTPM
- midbrain: 32 nTPM
- skin: 31 nTPM
- hypothalamus: 26 nTPM
- hippocampal formation: 25 nTPM
- basal ganglia: 18 nTPM
Single-cell type
- breast secretory cells: 947 nCPM
- enteric transient amplifying cells: 144 nCPM
- goblet cells: 142 nCPM
- colonocytes: 125 nCPM
- enteric stem cells: 120 nCPM
- tuft cells: 115 nCPM
Immune cell
- basophil: 2.5 nTPM
- memory CD8 T-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 91 nTPM
- spinal cord: 78 nTPM
- medulla oblongata: 74 nTPM
- hypothalamus: 54 nTPM
- cerebellum: 42 nTPM
- pons: 42 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0.6
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein SNORC
- Small Novel Rich in Cartilage
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SNORC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SNORC as an antibody target. Whether an autoantibody or antibody against SNORC could matter depends on whether native SNORC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SNORC is annotated as secreted, so native SNORC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SNORC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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