SNN
Stannin
Also known as: SNN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75324
- Gene
- SNN
- Ensembl
- ENSG00000184602
- Chromosome
- 16
- Canonical length
- 88 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Enables metal ion binding activity. Predicted to be involved in response to toxic substance. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
88 residues, UniProt reviewed canonical sequence.
>O75324|SNN
1 MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI VGDGETKEPF
61 LLVQYSAKGP CVERKAKLMT PNGPEVHGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SNN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 168 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 168 nTPM
- cerebral cortex: 135 nTPM
- amygdala: 118 nTPM
- hippocampal formation: 114 nTPM
- skeletal muscle: 111 nTPM
- midbrain: 110 nTPM
Single-cell type
- platelets: 652 nCPM
- neutrophils: 119 nCPM
- müller glia: 93 nCPM
- monocytes: 64 nCPM
- epididymal clear cells: 63 nCPM
- kupffer cells: 59 nCPM
Immune cell
- neutrophil: 53 nTPM
- non-classical monocyte: 49 nTPM
- intermediate monocyte: 36 nTPM
- classical monocyte: 21 nTPM
- myeloid DC: 20 nTPM
- total PBMC: 17 nTPM
Brain region
- basal ganglia: 179 nTPM
- hippocampal formation: 163 nTPM
- amygdala: 155 nTPM
- thalamus: 149 nTPM
- cerebral cortex: 140 nTPM
- midbrain: 135 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.75
- gnomAD pLI
- 0.14
- gnomAD missense Z
- 0.57
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Stannin transmembrane
- Stannin unstructured linker
- Stannin cytoplasmic
- Stannin superfamily
- Stannin
- Stannin transmembrane
- Stannin unstructured linker
- Stannin cytoplasmic
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SNN as an antibody target. Whether an autoantibody or antibody against SNN could matter depends on whether native SNN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SNN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SNN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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