Seroatlas · Human Serome Atlas

SNHG28

Putative uncharacterized protein SNHG28

Also known as: SNH28_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPA3
Gene: SNHG28
Canonical length: 235 aa

OverviewNCBI Gene

No narrative summary is available for SNHG28 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>P0DPA3|SNHG28
     1  MGMLAPGPLQ GRRPRKGHKG QEDAVAPGCK ASGRGSRVTH LLGYPTQNVS RSLRRKYAPP
    61  PCGGPEDVAL APCTAAAACE AGPSPVYVKV KSAEPADCAE GPVQCKNGLL VSSPHCEEPC
   121  AHSCAHPGLP PHLVHKLPLS YLQTQDTDAA SRRINAPLAA GWSWLRLWLV TLASGVDFPQ
   181  VSAWMRALPS PDCPGLRTTG EQMQKLLLKE NKVKTRKSKR RSGEGSHLTT SILEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNHG28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

V-set and immunoglobulin domain-containing protein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNHG28 as an antibody target. Whether an autoantibody or antibody against SNHG28 could matter depends on whether native SNHG28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNHG28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNHG28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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