SNCG

Protein identityUniProt · HPA

UniProt accession

O76070

Gene

SNCG

Ensembl

ENSG00000173267

Chromosome

10

Canonical length

127 aa

Protein class

Predicted intracellular proteins, Transporters

Subcellular location

Golgi apparatus,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>O76070|SNCG
     1  MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSVAEKTK
    61  EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGE ASKEKEEVAE
   121  EAQSGGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNCG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

638 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNCG.

Disease | ImmuneIEDB

Conditions an epitope on SNCG was assayed in.

• brain glioma T cell

ReferencesPubMed · IEDB

Publications for SNCG from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.63

gnomAD pLI

0

gnomAD missense Z

0.23

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adult locomotory behavior
• chemical synaptic transmission
• protein secretion
• regulation of dopamine secretion
• regulation of neurotransmitter secretion
• synapse organization
• synaptic vesicle endocytosis

Molecular functions

• cuprous ion binding

Cellular components

• axon terminus
• centrosome
• cytoplasm
• cytosol
• extracellular exosome
• Golgi apparatus
• neuronal cell body
• perinuclear region of cytoplasm
• spindle

Protein domainsUniProt · Pfam · InterPro

• Synuclein
• Synuclein
• Gamma-synuclein

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of SNCG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MYOC