Seroatlas · Human Serome Atlas

SNCB

Beta-synuclein

Also known as: SYUB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16143
Gene
SNCB
Ensembl
ENSG00000074317
Chromosome
5
Canonical length
134 aa
Protein class
Human disease related genes, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q16143|SNCB
     1  MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK
    61  EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE
   121  DPPQEEYQEY EPEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNCB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
563 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 563 nTPM
  • cerebellum: 411 nTPM
  • amygdala: 333 nTPM
  • hippocampal formation: 241 nTPM
  • hypothalamus: 188 nTPM
  • retina: 169 nTPM

Single-cell type

  • brain excitatory neurons: 72 nCPM
  • retinal bipolar cells: 70 nCPM
  • retinal amacrine cells: 65 nCPM
  • brain inhibitory neurons: 60 nCPM
  • rod photoreceptor cells: 51 nCPM
  • oocytes: 51 nCPM

Immune cell

  • naive B-cell: 0.6 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 1,093 nTPM
  • white matter: 663 nTPM
  • pons: 389 nTPM
  • basal ganglia: 385 nTPM
  • cerebellum: 319 nTPM
  • thalamus: 303 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNCB.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 24 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0.07
gnomAD missense Z
0.95
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNCB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNCB as an antibody target. Whether an autoantibody or antibody against SNCB could matter depends on whether native SNCB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNCB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNCB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNCB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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