SNAI3
Zinc finger protein SNAI3
Also known as: SMUC, SNAI3_HUMAN, Zfp293, ZNF293
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q3KNW1
- Gene
- SNAI3
- Ensembl
- ENSG00000185669
- Chromosome
- 16
- Canonical length
- 292 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>Q3KNW1|SNAI3
1 MPRSFLVKTH SSHRVPNYRR LETQREINGA CSACGGLVVP LLPRDKEAPS VPGDLPQPWD
61 RSSAVACISL PLLPRIEEAL GASGLDALEV SEVDPRASRA AIVPLKDSLN HLNLPPLLVL
121 PTRWSPTLGP DRHGAPEKLL GAERMPRAPG GFECFHCHKP YHTLAGLARH RQLHCHLQVG
181 RVFTCKYCDK EYTSLGALKM HIRTHTLPCT CKICGKAFSR PWLLQGHVRT HTGEKPYACS
241 HCSRAFADRS NLRAHLQTHS DAKKYRCRRC TKTFSRMSLL ARHEESGCCP GPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SNAI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 29 nTPM
- tongue: 6.8 nTPM
- spleen: 6.5 nTPM
- lymph node: 3.6 nTPM
- small intestine: 3.4 nTPM
- stomach: 3.1 nTPM
Single-cell type
- early primary spermatocytes: 47 nCPM
- myonuclei: 45 nCPM
- neutrophils: 25 nCPM
- differentiating spermatogonia: 23 nCPM
- plasma cells: 22 nCPM
- nk-cells: 20 nCPM
Immune cell
- eosinophil: 49 nTPM
- neutrophil: 31 nTPM
- T-reg: 21 nTPM
- MAIT T-cell: 19 nTPM
- memory CD4 T-cell: 17 nTPM
- myeloid DC: 17 nTPM
Brain region
- cerebral cortex: 27 nTPM
- pons: 25 nTPM
- hippocampal formation: 24 nTPM
- amygdala: 22 nTPM
- basal ganglia: 19 nTPM
- white matter: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.14
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.87
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- copper ion binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SNAI3 as an antibody target. Whether an autoantibody or antibody against SNAI3 could matter depends on whether native SNAI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SNAI3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SNAI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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