Seroatlas · Human Serome Atlas

SMTNL2

Smoothelin-like protein 2

Also known as: FLJ42461, SMTL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAL5
Gene: SMTNL2
Ensembl: ENSG00000188176
Chromosome: 17
Canonical length: 461 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

No narrative summary is available for SMTNL2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q2TAL5|SMTNL2
     1  MEPAPDAQEA RTVREALGRY EAALEGAVRA LHEDMRGLQR GVERRVAEAM RLAGPLARTV
    61  ADLQRDNQRL QAQLERLTRQ VEALGLASGM SPVPGTPGTP SPPPAPGVPD RAPRLGSARF
   121  ASHATFSLSG RGQSLDHDEA SESEMRKTSN SCIMENGHQP GAGPGDGPPE IAQNFSAPDP
   181  PRPRPVSLSL RLPHQPVTAI TRVSDRFSGE TSAAALSPMS AATLGGLNPS PSEVITPWTP
   241  SPSEKNSSFT WSVPSSGYGA VTASKHSNSP PLVTPPQSPV SPQPPAITQV HRQGERRREL
   301  VRSQTLPRTS EAQARKALFE KWEQETAAGK GKGEARARLK RSQSFGVASA SSIKQILLEW
   361  CRSKTLGYQH VDLQNFSSSW SDGMAFCALV HSFFPDAFDY NSLSPTQRQK NFELAFTMAE
   421  NLANCERLIE VEDMMVMGRK PDPMCVFTYV QSLYNHLRRF E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMTNL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 477 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 477 nTPM
tongue: 127 nTPM
kidney: 37 nTPM
heart muscle: 17 nTPM
fallopian tube: 8.7 nTPM
adipose tissue: 7.8 nTPM

Single-cell type

myonuclei: 164 nCPM
proximal tubule cells: 60 nCPM
loop of henle epithelial cells: 52 nCPM
epicardial cells: 41 nCPM
distal convoluted tubule cells: 37 nCPM
mesothelial cells: 32 nCPM

Immune cell

intermediate monocyte: 0.3 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hippocampal formation: 4.5 nTPM
cerebral cortex: 2.2 nTPM
basal ganglia: 1.4 nTPM
choroid plexus: 1.1 nTPM
midbrain: 1 nTPM
pons: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMTNL2 as an antibody target. Whether an autoantibody or antibody against SMTNL2 could matter depends on whether native SMTNL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMTNL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMTNL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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