Seroatlas · Human Serome Atlas

SMTNL1

Smoothelin-like protein 1

Also known as: CHASM, SMTL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MU46
Gene: SMTNL1
Ensembl: ENSG00000214872
Chromosome: 11
Canonical length: 494 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is involved in the contraction of both striated and smooth muscle. During pregnancy, the encoded protein interacts with progesterone receptor to attenuate the expression of contractile and metabolic proteins. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>A8MU46|SMTNL1
     1  MEQKEGKLSE DGTTVSPAAD NPEMSGGGAP AEETKGTAGK AINEGPPTES GKQEKAPAED
    61  GMSAELQGEA NGLDEVKVES QREAGGKEDA EAELKKEDGE KEETTVGSQE MTGRKEETKS
   121  EPKEAEEKES TLASEKQKAE EKEAKPESGQ KADANDRDKP EPKATVEEED AKTASQEETG
   181  QRKECSTEPK EKATDEEAKA ESQKAVVEDE AKAEPKEPDG KEEAKHGAKE EADAKEEAED
   241  AEEAEPGSPS EEQEQDVEKE PEGGAGVIPS SPEEWPESPT GEGHNLSTDG LGPDCVASGQ
   301  TSPSASESSP SDVPQSPPES PSSGEKKEKA PERRVSAPAR PRGPRAQNRK AIVDKFGGAA
   361  SGPTALFRNT KAAGAAIGGV KNMLLEWCRA MTKKYEHVDI QNFSSSWSSG MAFCALIHKF
   421  FPDAFDYAEL DPAKRRHNFT LAFSTAEKLA DCAQLLDVDD MVRLAVPDSK CVYTYIQELY
   481  RSLVQKGLVK TKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMTNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 652 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 652 nTPM
tongue: 175 nTPM
esophagus: 8 nTPM
salivary gland: 5.8 nTPM
bone marrow: 2.1 nTPM
prostate: 1.4 nTPM

Single-cell type

myonuclei: 109 nCPM
epicardial cells: 11 nCPM
thymic myoid cells: 5.4 nCPM
hematopoietic stem cells: 4.9 nCPM
retinal amacrine cells: 4.9 nCPM
mesothelial cells: 4.5 nCPM

Immune cell

neutrophil: 1 nTPM
eosinophil: 0.7 nTPM
basophil: 0.6 nTPM
naive CD4 T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
MAIT T-cell: 0.4 nTPM

Brain region

medulla oblongata: 8.8 nTPM
spinal cord: 6 nTPM
thalamus: 5.5 nTPM
midbrain: 5.1 nTPM
amygdala: 4.7 nTPM
cerebral cortex: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.43

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMTNL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1R12A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMTNL1 as an antibody target. Whether an autoantibody or antibody against SMTNL1 could matter depends on whether native SMTNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMTNL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMTNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...