Seroatlas · Human Serome Atlas

SMOC2

SPARC-related modular calcium-binding protein 2

Also known as: SMAP2, SMOC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H3U7
Gene
SMOC2
Ensembl
ENSG00000112562
Chromosome
6
Canonical length
446 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q9H3U7|SMOC2
     1  MLLPQLCWLP LLAGLLPPVP AQKFSALTFL RVDQDKDKDC SLDCAGSPQK PLCASDGRTF
    61  LSRCEFQRAK CKDPQLEIAY RGNCKDVSRC VAERKYTQEQ ARKEFQQVFI PECNDDGTYS
   121  QVQCHSYTGY CWCVTPNGRP ISGTAVAHKT PRCPGSVNEK LPQREGTGKT DDAAAPALET
   181  QPQGDEEDIA SRYPTLWTEQ VKSRQNKTNK NSVSSCDQEH QSALEEAKQP KNDNVVIPEC
   241  AHGGLYKPVQ CHPSTGYCWC VLVDTGRPIP GTSTRYEQPK CDNTARAHPA KARDLYKGRQ
   301  LQGCPGAKKH EFLTSVLDAL STDMVHAASD PSSSSGRLSE PDPSHTLEER VVHWYFKLLD
   361  KNSSGDIGKK EIKPFKRFLR KKSKPKKCVK KFVEYCDVNN DKSISVQELM GCLGVAKEDG
   421  KADTKKRHTP RGHAESTSNR QPRKQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMOC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
408 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 408 nTPM
  • ovary: 182 nTPM
  • endometrium: 141 nTPM
  • fallopian tube: 131 nTPM
  • stomach: 124 nTPM
  • cervix: 121 nTPM

Single-cell type

  • peritubular myoid cells: 1,219 nCPM
  • fibro-adipogenic progenitors: 882 nCPM
  • leydig cells: 766 nCPM
  • paneth cells: 611 nCPM
  • enteric stem cells: 429 nCPM
  • mesothelial cells: 302 nCPM

Immune cell

  • naive B-cell: 0.7 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 76 nTPM
  • basal ganglia: 10 nTPM
  • thalamus: 9.3 nTPM
  • pons: 8.9 nTPM
  • medulla oblongata: 8.7 nTPM
  • midbrain: 8.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SMOC2.

Disease | AllUniProt

Conditions SMOC2 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 196 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Dentin dysplasia type I

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0
gnomAD missense Z
0.64
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMOC2 as an antibody target. Whether an autoantibody or antibody against SMOC2 could matter depends on whether native SMOC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMOC2 is annotated as secreted, so native SMOC2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SMOC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMOC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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