Seroatlas · Human Serome Atlas

SMLR1

Small leucine-rich protein 1

Also known as: SMLR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BR10
Gene
SMLR1
Ensembl
ENSG00000256162
Chromosome
6
Canonical length
107 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>H3BR10|SMLR1
     1  MLSKGRSPRR KQVQTQRKAA LVLSVTPMVP VGSVWLAMSS VLSAFMRELP GWFLFFGVFL
    61  PVTLLLLLLI AYFRIKLIEV NEELSQNCDR QHNPKDGSSL YQRMKWT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMLR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • liver: 53 nTPM
  • duodenum: 11 nTPM
  • small intestine: 9.8 nTPM
  • kidney: 3 nTPM
  • retina: 1 nTPM
  • adrenal gland: 0.3 nTPM

Single-cell type

  • hepatocytes: 289 nCPM
  • enterocytes: 155 nCPM
  • cholangiocytes: 9.9 nCPM
  • paneth cells: 7.7 nCPM
  • adipocytes: 7 nCPM
  • epicardial cells: 6.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 3.4 nTPM
  • cerebral cortex: 2.8 nTPM
  • white matter: 2 nTPM
  • medulla oblongata: 1.9 nTPM
  • hippocampal formation: 1.6 nTPM
  • pons: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0.2
gnomAD missense Z
0.18
DepMap mean gene effect
0.05
DepMap dependency class
none

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMLR1 as an antibody target. Whether an autoantibody or antibody against SMLR1 could matter depends on whether native SMLR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMLR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMLR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMLR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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