Seroatlas · Human Serome Atlas

SMKR1

Small lysine-rich protein 1

Also known as: SMKR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BMG3
Gene
SMKR1
Ensembl
ENSG00000240204
Chromosome
7
Canonical length
65 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

No narrative summary is available for SMKR1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

65 residues, UniProt reviewed canonical sequence.

>H3BMG3|SMKR1
     1  MPAKGKKGKG QGKSHGKKQK KPEVDILSPA AMLNLYYIAH NVADCLHLRG FHWPGAPKGK
    61  KGRSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMKR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
131 nTPM

Expression across tissuesHPA

Tissue

  • testis: 131 nTPM
  • basal ganglia: 11 nTPM
  • cerebral cortex: 7.3 nTPM
  • pituitary gland: 6.4 nTPM
  • fallopian tube: 6.2 nTPM
  • parathyroid gland: 6 nTPM

Single-cell type

  • late spermatids: 10,429 nCPM
  • early spermatids: 2,164 nCPM
  • late primary spermatocytes: 631 nCPM
  • oocytes: 276 nCPM
  • respiratory ciliated cells: 37 nCPM
  • epididymal efferent duct ciliated cells: 33 nCPM

Immune cell

  • gdT-cell: 1.3 nTPM
  • memory B-cell: 1 nTPM
  • naive B-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • MAIT T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.5 nTPM

Brain region

  • hypothalamus: 5.7 nTPM
  • basal ganglia: 4.8 nTPM
  • cerebral cortex: 3.9 nTPM
  • white matter: 3.5 nTPM
  • hippocampal formation: 3.4 nTPM
  • midbrain: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0.44
gnomAD missense Z
0.75
DepMap mean gene effect
0.04
DepMap dependency class
none

Protein domainsUniProt · Pfam · InterPro

  • Small lysine-rich protein 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMKR1 as an antibody target. Whether an autoantibody or antibody against SMKR1 could matter depends on whether native SMKR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMKR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMKR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMKR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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