Seroatlas · Human Serome Atlas

SMIM8

Small integral membrane protein 8

Also known as: C6orf162, dJ102H19.2, DKFZP586E1923, SMIM8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96KF7
Gene
SMIM8
Ensembl
ENSG00000111850
Chromosome
6
Canonical length
97 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>Q96KF7|SMIM8
     1  MSSAPEPPTF KKEPPKEKEF QSPGLRGVRT TTLFRAVNPE LFIKPNKPVM AFGLVTLSLC
    61  VAYIGYLHAI QENKKDLYEA IDSEGHSYMR RKTSKWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 11 nTPM
  • cerebellum: 10 nTPM
  • skeletal muscle: 9.9 nTPM
  • amygdala: 8.5 nTPM
  • basal ganglia: 8.4 nTPM
  • hippocampal formation: 8.3 nTPM

Single-cell type

  • myonuclei: 150 nCPM
  • choroid plexus epithelial cells: 150 nCPM
  • neutrophil progenitors: 128 nCPM
  • ependymal cells: 125 nCPM
  • gonadotrophs: 116 nCPM
  • distal convoluted tubule cells: 109 nCPM

Immune cell

  • naive CD4 T-cell: 19 nTPM
  • memory B-cell: 19 nTPM
  • T-reg: 19 nTPM
  • naive CD8 T-cell: 17 nTPM
  • eosinophil: 16 nTPM
  • neutrophil: 15 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • cerebellum: 11 nTPM
  • hypothalamus: 11 nTPM
  • choroid plexus: 10 nTPM
  • spinal cord: 10 nTPM
  • basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0.01
gnomAD missense Z
-0.22
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • UPF0708 protein C6orf162
  • Domain of unknown function (DUF4500)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM8 as an antibody target. Whether an autoantibody or antibody against SMIM8 could matter depends on whether native SMIM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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