Seroatlas · Human Serome Atlas

SMIM5

Small integral membrane protein 5

Also known as: C17orf109, SMIM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q71RC9
Gene
SMIM5
Ensembl
ENSG00000204323
Chromosome
17
Canonical length
77 aa
Protein class
Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

77 residues, UniProt reviewed canonical sequence.

>Q71RC9|SMIM5
     1  MAATDFVQEM RAVGERLLLK LQRLPQAEPV EIVAFSVIIL FTATVLLLLL IACSCCCTHC
    61  CCPERRGRKV QVQPTPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 33 nTPM
  • esophagus: 27 nTPM
  • choroid plexus: 22 nTPM
  • spinal cord: 19 nTPM
  • thyroid gland: 15 nTPM
  • small intestine: 15 nTPM

Single-cell type

  • esophageal apical cells: 1,336 nCPM
  • platelets: 417 nCPM
  • esophageal suprabasal cells: 191 nCPM
  • salivary duct cells: 148 nCPM
  • urothelial cells: 139 nCPM
  • endometrial luminal cells: 102 nCPM

Immune cell

  • plasmacytoid DC: 208 nTPM
  • total PBMC: 14 nTPM
  • neutrophil: 3.7 nTPM
  • basophil: 1.1 nTPM
  • eosinophil: 0.6 nTPM
  • classical monocyte: 0.3 nTPM

Brain region

  • white matter: 32 nTPM
  • medulla oblongata: 23 nTPM
  • choroid plexus: 21 nTPM
  • pons: 18 nTPM
  • midbrain: 17 nTPM
  • cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0.13
gnomAD missense Z
0.19
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM5 as an antibody target. Whether an autoantibody or antibody against SMIM5 could matter depends on whether native SMIM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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