SMIM47
Small integral membrane protein 47
Also known as: SIM47_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for SMIM47 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
28 residues, UniProt reviewed canonical sequence.
>D0EPY3|SMIM47
1 MNFQENVTLA MALFTILTSI YFFNKAQQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SMIM47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.51
OntologyGO
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SMIM47 as an antibody target. Whether an autoantibody or antibody against SMIM47 could matter depends on whether native SMIM47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SMIM47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SMIM47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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