Seroatlas · Human Serome Atlas

SMIM46

Small integral membrane protein 46

Also known as: SIM46_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DQW1
Gene
SMIM46
Canonical length
50 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for SMIM46 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

50 residues, UniProt reviewed canonical sequence.

>P0DQW1|SMIM46
     1  MDLGSGSSQG GDLETTFQLW LQLLLWAHLA VRFLGYLHRT FRGPKPQPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 11 nTPM
  • ovary: 1.6 nTPM
  • adrenal gland: 1.5 nTPM
  • adipose tissue: 1.1 nTPM
  • testis: 1.1 nTPM
  • skeletal muscle: 1 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 4.1 nTPM
  • midbrain: 3.2 nTPM
  • medulla oblongata: 2.5 nTPM
  • pons: 2.5 nTPM
  • basal ganglia: 2.2 nTPM
  • white matter: 1.9 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM46 as an antibody target. Whether an autoantibody or antibody against SMIM46 could matter depends on whether native SMIM46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM46. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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