Seroatlas · Human Serome Atlas

SMIM45

Small integral membrane protein 45

Also known as: SMI45_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A590UK83
Gene: SMIM45
Canonical length: 68 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for SMIM45 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>A0A590UK83|SMIM45
     1  MPHFLDWFVP VYLVISVLIL VGFGACIYYF EPGLQEAHKW RMQRPLVDRD LRKTLMVRDN
    61  LAFGGPEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 39 nTPM
hippocampal formation: 38 nTPM
cerebral cortex: 34 nTPM
amygdala: 33 nTPM
hypothalamus: 19 nTPM
midbrain: 14 nTPM

Single-cell type

late primary spermatocytes: 17 nCPM
retinal bipolar cells: 13 nCPM
early spermatids: 11 nCPM
adrenal medulla cells: 11 nCPM
other brain neurons: 10 nCPM
brain inhibitory neurons: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 43 nTPM
hippocampal formation: 42 nTPM
cerebral cortex: 42 nTPM
amygdala: 36 nTPM
basal ganglia: 33 nTPM
midbrain: 29 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

neuron maturation

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM45 as an antibody target. Whether an autoantibody or antibody against SMIM45 could matter depends on whether native SMIM45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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