Seroatlas · Human Serome Atlas

SMIM44

Small integral membrane protein 44

Also known as: SMI44_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A286YF18
Gene: SMIM44
Ensembl: ENSG00000284638
Chromosome: 19
Canonical length: 149 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>A0A286YF18|SMIM44
     1  MPGLAAEGEA EGWSPSPPLY EEYRPPPLDS IRLPRYVLYL LLAALVVVAV AYAIVGHLIK
    61  DLAHDLADWA FGPKPDQEAA PRELRPSLTG EDLEGLDLQL ALAWQGEEDA GGGGEGAPSE
   121  PPPPPEPRRP SIAFKDPPSR SSFWKLMAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

retina: 17 nTPM
duodenum: 13 nTPM
small intestine: 9.3 nTPM
stomach: 2.8 nTPM
bone marrow: 2.3 nTPM
colon: 1.7 nTPM

Single-cell type

epididymal principal cells: 7.3 nCPM
epididymal clear cells: 6.1 nCPM
enterocytes: 6 nCPM
foveolar cells: 4.3 nCPM
retinal pigment epithelial cells: 4.3 nCPM
rod photoreceptor cells: 3.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 4.6 nTPM
cerebellum: 0.8 nTPM
white matter: 0.8 nTPM
basal ganglia: 0.6 nTPM
thalamus: 0.4 nTPM
cerebral cortex: 0.3 nTPM

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM44 as an antibody target. Whether an autoantibody or antibody against SMIM44 could matter depends on whether native SMIM44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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