Seroatlas · Human Serome Atlas

SMIM42

Small integral membrane protein 42

Also known as: SIM42_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A5F9ZH02
Gene
SMIM42
Ensembl
ENSG00000288460
Chromosome
1
Canonical length
70 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

70 residues, UniProt reviewed canonical sequence.

>A0A5F9ZH02|SMIM42
     1  MSSPQLPAFL WDKGTLTTAI SNPACLVNVL FFFTPLMTLV TLLILVWKVT KDKSNKNRET
    61  HPRKEATWLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
8.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 8.6 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late primary spermatocytes: 57 nCPM
  • early spermatids: 26 nCPM
  • late spermatids: 4.4 nCPM
  • epicardial cells: 2.3 nCPM
  • endometrial stromal cells: 0.3 nCPM
  • peritubular myoid cells: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • pons: 0.1 nTPM
  • basal ganglia: 0 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM42 as an antibody target. Whether an autoantibody or antibody against SMIM42 could matter depends on whether native SMIM42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...