Seroatlas · Human Serome Atlas

SMIM41

Small integral membrane protein 41

Also known as: SIM41_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A2R8YCJ5
Gene
SMIM41
Ensembl
ENSG00000284791
Chromosome
12
Canonical length
93 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>A0A2R8YCJ5|SMIM41
     1  MNGSQAGAAA QAAWLSSCCN QSASPPEPPE GPRAVQAVVL GVLSLLVLCG VLFLGGGLLL
    61  RAQGLTALLT REQRASREPE PGSASGEDGD DDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • lung: 19 nTPM
  • prostate: 6.7 nTPM
  • testis: 4.8 nTPM
  • spleen: 4.5 nTPM
  • ovary: 3.2 nTPM
  • urinary bladder: 2.6 nTPM

Single-cell type

  • peritubular myoid cells: 41 nCPM
  • leydig cells: 20 nCPM
  • renal collecting duct intercalated cells: 13 nCPM
  • breast myoepithelial cells: 10 nCPM
  • renal collecting duct principal cells: 10 nCPM
  • paneth cells: 7.7 nCPM

Immune cell

  • plasmacytoid DC: 5.8 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.9 nTPM
  • medulla oblongata: 0.9 nTPM
  • pons: 0.4 nTPM
  • spinal cord: 0.3 nTPM
  • midbrain: 0.2 nTPM
  • white matter: 0.2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM41 as an antibody target. Whether an autoantibody or antibody against SMIM41 could matter depends on whether native SMIM41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM41. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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