Seroatlas · Human Serome Atlas

SMIM39

Small integral membrane protein 39

Also known as: SIM39_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GW54
Gene
SMIM39
Ensembl
ENSG00000284479
Chromosome
2
Canonical length
56 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

56 residues, UniProt reviewed canonical sequence.

>A0A1B0GW54|SMIM39
     1  MARAPQPRRG PAAPGNALRA LLRCNLPPGA QRVVVSAVLA LLVLINVVLI FLLAFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
1.1 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 1.1 nTPM
  • fallopian tube: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • midbrain: 0.3 nTPM
  • spinal cord: 0.3 nTPM
  • colon: 0.2 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 14 nTPM
  • cerebral cortex: 12 nTPM
  • hippocampal formation: 12 nTPM
  • hypothalamus: 12 nTPM
  • medulla oblongata: 12 nTPM
  • white matter: 11 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM39 as an antibody target. Whether an autoantibody or antibody against SMIM39 could matter depends on whether native SMIM39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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