Seroatlas · Human Serome Atlas

SMIM38

Small integral membrane protein 38

Also known as: SIM38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A286YFK9
Gene
SMIM38
Ensembl
ENSG00000284713
Chromosome
11
Canonical length
51 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

51 residues, UniProt reviewed canonical sequence.

>A0A286YFK9|SMIM38
     1  MTSWPGGSFG PDPLLALLVV ILLARLILWS CLGTYIDYRL AQRRPQKPKQ D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 33 nTPM
  • pancreas: 3.1 nTPM
  • kidney: 2.4 nTPM
  • testis: 1.3 nTPM
  • cervix: 0.8 nTPM
  • colon: 0.7 nTPM

Single-cell type

  • parietal cells: 1.8 nCPM
  • gastric chief cells: 1.1 nCPM
  • oligodendrocyte progenitor cells: 0.6 nCPM
  • brain excitatory neurons: 0.4 nCPM
  • brain inhibitory neurons: 0.4 nCPM
  • other brain neurons: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 6.7 nTPM
  • basal ganglia: 4.6 nTPM
  • white matter: 4.3 nTPM
  • cerebellum: 3.9 nTPM
  • amygdala: 3.2 nTPM
  • pons: 3.2 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM38 as an antibody target. Whether an autoantibody or antibody against SMIM38 could matter depends on whether native SMIM38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM38. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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