Seroatlas · Human Serome Atlas

SMIM36

Small integral membrane protein 36

Also known as: SIM36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVT2
Gene
SMIM36
Ensembl
ENSG00000261873
Chromosome
17
Canonical length
93 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>A0A1B0GVT2|SMIM36
     1  MEFYLEIDPV TLNLIILVAS YVILLLVFLI SCVLYDCRGK DPSKEYAPEA TLEAQPSIRL
    61  VVMHPSVAGP HWPKGPGLSL GDPAPLGKKS TMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • retina: 10 nTPM
  • testis: 2.6 nTPM
  • bone marrow: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • spleen: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • rod photoreceptor cells: 507 nCPM
  • retinal bipolar cells: 433 nCPM
  • late primary spermatocytes: 70 nCPM
  • adipocytes: 56 nCPM
  • retinal ganglion cells: 54 nCPM
  • epicardial cells: 23 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 1.9 nTPM
  • amygdala: 1.3 nTPM
  • basal ganglia: 1.3 nTPM
  • hippocampal formation: 1.3 nTPM
  • white matter: 1.2 nTPM
  • cerebellum: 0.8 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM36 as an antibody target. Whether an autoantibody or antibody against SMIM36 could matter depends on whether native SMIM36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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