Seroatlas · Human Serome Atlas

SMIM35

Small integral membrane protein 35

Also known as: SIM35_HUMAN, TMPRSS4-AS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVV1
Gene
SMIM35
Ensembl
ENSG00000255274
Chromosome
11
Canonical length
85 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>A0A1B0GVV1|SMIM35
     1  MTGEDSISTL GLILGVGLLL LLVSILGYSL AKWYQRGYCW EGPNFVFNLY QIRNLKDLEM
    61  GPPFTISGHI SSTDGGYMKF SNGLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
1.2 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 1.2 nTPM
  • kidney: 1.1 nTPM
  • lymph node: 0.6 nTPM
  • appendix: 0.5 nTPM
  • spleen: 0.5 nTPM
  • tonsil: 0.5 nTPM

Single-cell type

  • microglia: 130 nCPM
  • kupffer cells: 39 nCPM
  • proximal tubule cells: 22 nCPM
  • papillary tip epithelial cells: 15 nCPM
  • respiratory ciliated cells: 13 nCPM
  • myosatellite cells: 12 nCPM

Immune cell

  • T-reg: 1.6 nTPM
  • memory B-cell: 0.5 nTPM
  • NK-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • gdT-cell: 0.2 nTPM

Brain region

  • cerebral cortex: 1.2 nTPM
  • basal ganglia: 0.8 nTPM
  • pons: 0.7 nTPM
  • medulla oblongata: 0.6 nTPM
  • thalamus: 0.6 nTPM
  • hippocampal formation: 0.5 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM35 as an antibody target. Whether an autoantibody or antibody against SMIM35 could matter depends on whether native SMIM35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM35. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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