Seroatlas · Human Serome Atlas

SMIM34

Small integral membrane protein 34

Also known as: SM34A_HUMAN, SMIM34A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MWV9
Gene
SMIM34
Ensembl
ENSG00000243627
Chromosome
21
Canonical length
139 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>A8MWV9|SMIM34
     1  MEWAKWTPHE ASNQTQASTL LGLLLGDHTE GRNDTNSTRA LKVPDGTSAA WYILTIIGIY
    61  AVIFVFRLAS NILRKNDKSL EDVYYSNLTS ELKMTGLQGK VAKCSTLSIS NRAVLQPCQA
   121  HLGAKGGSSG PQTATPETP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
6.5 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 6.5 nTPM
  • breast: 1.9 nTPM
  • choroid plexus: 1.6 nTPM
  • fallopian tube: 1.5 nTPM
  • cerebellum: 0.7 nTPM
  • lung: 0.6 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 5.5 nTPM
  • cerebellum: 3.5 nTPM
  • cerebral cortex: 3.5 nTPM
  • basal ganglia: 3.3 nTPM
  • hippocampal formation: 3.3 nTPM
  • midbrain: 2.6 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM34 as an antibody target. Whether an autoantibody or antibody against SMIM34 could matter depends on whether native SMIM34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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