Seroatlas · Human Serome Atlas

SMIM32

Small integral membrane protein 32

Also known as: SIM32_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUA5
Gene
SMIM32
Ensembl
ENSG00000271824
Chromosome
5
Canonical length
103 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>A0A1B0GUA5|SMIM32
     1  MYGDIFNATG GPEAAVGSAL APGATVKAEG ALPLELATAR GMRDGAATKP DLPTYLLLFF
    61  LLLLSVALVV LFIGCQLRHS AFAALPHDRS LRDARAPWKT RPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 48 nTPM
  • duodenum: 12 nTPM
  • basal ganglia: 6.4 nTPM
  • small intestine: 5.8 nTPM
  • colon: 4.6 nTPM
  • cerebral cortex: 3.9 nTPM

Single-cell type

  • neuroendocrine cells: 36 nCPM
  • enterocytes: 31 nCPM
  • colonocytes: 26 nCPM
  • enteric transient amplifying cells: 18 nCPM
  • pancreatic islet cells: 17 nCPM
  • enteric stem cells: 17 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 38 nTPM
  • cerebellum: 4.5 nTPM
  • white matter: 4.3 nTPM
  • basal ganglia: 4 nTPM
  • midbrain: 3.7 nTPM
  • hypothalamus: 3.5 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM32 as an antibody target. Whether an autoantibody or antibody against SMIM32 could matter depends on whether native SMIM32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM32. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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