Seroatlas · Human Serome Atlas

SMIM31

Small integral membrane protein 31

Also known as: h.EPR, LINC01207, SIM31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVY4
Gene
SMIM31
Ensembl
ENSG00000248771
Chromosome
4
Canonical length
71 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

71 residues, UniProt reviewed canonical sequence.

>A0A1B0GVY4|SMIM31
     1  MELPYTNLEM AFILLAFVIF SLFTLASIYT TPDDSNEEEE HEKKGREKKR KKSEKKKNCS
    61  EEEHRIEAVE L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 23 nTPM
  • duodenum: 21 nTPM
  • rectum: 15 nTPM
  • colon: 15 nTPM
  • prostate: 10 nTPM
  • gallbladder: 7.4 nTPM

Single-cell type

  • enterocytes: 202 nCPM
  • goblet cells: 179 nCPM
  • colonocytes: 151 nCPM
  • respiratory secretory cells: 117 nCPM
  • gastric progenitor cells: 108 nCPM
  • paneth cells: 77 nCPM

Immune cell

  • basophil: 1 nTPM
  • neutrophil: 0.5 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • cerebellum: 2.6 nTPM
  • white matter: 2.6 nTPM
  • cerebral cortex: 2.4 nTPM
  • choroid plexus: 2.4 nTPM
  • amygdala: 2.2 nTPM
  • medulla oblongata: 2.2 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM31 as an antibody target. Whether an autoantibody or antibody against SMIM31 could matter depends on whether native SMIM31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM31. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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