Seroatlas · Human Serome Atlas

SMIM30

Small integral membrane protein 30

Also known as: LINC00998, SIM30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A4D0T7
Gene
SMIM30
Ensembl
ENSG00000214194
Chromosome
7
Canonical length
59 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Involved in negative regulation of type I interferon-mediated signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

59 residues, UniProt reviewed canonical sequence.

>A4D0T7|SMIM30
     1  MTSVSTQLSL VLMSLLLVLP VVEAVEAGDA IALLLGVVLS ITGICACLGV YARKRNGQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
192 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 192 nTPM
  • tongue: 140 nTPM
  • skeletal muscle: 133 nTPM
  • parathyroid gland: 79 nTPM
  • kidney: 78 nTPM
  • epididymis: 67 nTPM

Single-cell type

  • hofbauer cells: 354 nCPM
  • parietal cells: 281 nCPM
  • esophageal apical cells: 246 nCPM
  • esophageal suprabasal cells: 194 nCPM
  • kupffer cells: 141 nCPM
  • megakaryocytes: 118 nCPM

Immune cell

  • plasmacytoid DC: 37 nTPM
  • myeloid DC: 25 nTPM
  • T-reg: 23 nTPM
  • NK-cell: 20 nTPM
  • memory B-cell: 20 nTPM
  • memory CD4 T-cell: 18 nTPM

Brain region

  • white matter: 29 nTPM
  • medulla oblongata: 26 nTPM
  • hypothalamus: 25 nTPM
  • spinal cord: 24 nTPM
  • cerebellum: 22 nTPM
  • basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.75
gnomAD pLI
0.38

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4730
  • Domain of unknown function (DUF4730)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM30 as an antibody target. Whether an autoantibody or antibody against SMIM30 could matter depends on whether native SMIM30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM30. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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