Seroatlas · Human Serome Atlas

SMIM29

Small integral membrane protein 29

Also known as: C6orf1, LBH, MGC57858, SIM29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86T20
Gene
SMIM29
Ensembl
ENSG00000186577
Chromosome
6
Canonical length
102 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>Q86T20|SMIM29
     1  MSNTTVPNAP QANSDSMVGY VLGPFFLITL VGVVVAVVMY VQKKKRVDRL RHHLLPMYSY
    61  DPAEELHEAE QELLSDMGDP KVVHGWQSGY QHKRMPLLDV KT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
149 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 149 nTPM
  • cerebral cortex: 133 nTPM
  • midbrain: 121 nTPM
  • hippocampal formation: 120 nTPM
  • hypothalamus: 118 nTPM
  • spinal cord: 88 nTPM

Single-cell type

  • hofbauer cells: 153 nCPM
  • melanocytes: 101 nCPM
  • esophageal suprabasal cells: 87 nCPM
  • esophageal basal cells: 74 nCPM
  • epididymal principal cells: 73 nCPM
  • esophageal apical cells: 61 nCPM

Immune cell

  • eosinophil: 414 nTPM
  • neutrophil: 233 nTPM
  • memory B-cell: 134 nTPM
  • naive B-cell: 127 nTPM
  • basophil: 100 nTPM
  • T-reg: 91 nTPM

Brain region

  • pons: 116 nTPM
  • thalamus: 110 nTPM
  • medulla oblongata: 106 nTPM
  • midbrain: 103 nTPM
  • hypothalamus: 99 nTPM
  • spinal cord: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0.62
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small integral membrane protein 29

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM29 as an antibody target. Whether an autoantibody or antibody against SMIM29 could matter depends on whether native SMIM29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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