Seroatlas · Human Serome Atlas

SMIM28

Small integral membrane protein 28

Also known as: SIM28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GU29
Gene
SMIM28
Ensembl
ENSG00000262543
Chromosome
6
Canonical length
152 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>A0A1B0GU29|SMIM28
     1  MRGLLGSSWK KFGHAGRGTY EWLTSEPGLP LLETQLQGTQ GVSSTQEDVE PFLCILLPAT
    61  ILLFLAFLLL FLYRRCKSPP PQGQVFSIDL PEHPPAGEVT DLLPGLAWSS EDFPYSPLPP
   121  EATLPSQCLP PSYEEATRNP PGEEAQGCSP SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • colon: 2.5 nTPM
  • parathyroid gland: 0.5 nTPM
  • small intestine: 0.5 nTPM
  • appendix: 0.4 nTPM
  • rectum: 0.4 nTPM
  • smooth muscle: 0.3 nTPM

Single-cell type

  • prostatic glandular cells: 1.1 nCPM
  • conjunctival goblet cells: 1 nCPM
  • pancreatic islet cells: 1 nCPM
  • early spermatids: 0.9 nCPM
  • mucous neck cells: 0.8 nCPM
  • neuroendocrine cells: 0.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM28 as an antibody target. Whether an autoantibody or antibody against SMIM28 could matter depends on whether native SMIM28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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