SMIM27
Small integral membrane protein 27
Also known as: C9orf133, SIM27_HUMAN, TOPORS-AS1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1B0GUW7
- Gene
- SMIM27
- Ensembl
- ENSG00000235453
- Chromosome
- 9
- Canonical length
- 55 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
OverviewNCBI Gene
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
55 residues, UniProt reviewed canonical sequence.
>A0A1B0GUW7|SMIM27
1 MKPVSRRTLD WIYSVLLLAI VLISWGCIIY ASMVSARRQL RKKYPDKIFG TNENLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SMIM27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 39 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 39 nTPM
- testis: 36 nTPM
- skeletal muscle: 30 nTPM
- pancreas: 27 nTPM
- tongue: 24 nTPM
- thymus: 24 nTPM
Single-cell type
- early spermatids: 422 nCPM
- late primary spermatocytes: 364 nCPM
- late spermatids: 234 nCPM
- platelets: 152 nCPM
- parietal cells: 143 nCPM
- cardiomyocytes: 116 nCPM
Immune cell
- neutrophil: 758 nTPM
- eosinophil: 363 nTPM
- naive CD4 T-cell: 146 nTPM
- T-reg: 138 nTPM
- naive B-cell: 137 nTPM
- memory B-cell: 132 nTPM
Brain region
- white matter: 27 nTPM
- spinal cord: 23 nTPM
- hypothalamus: 23 nTPM
- cerebellum: 23 nTPM
- cerebral cortex: 22 nTPM
- medulla oblongata: 22 nTPM
OntologyGO
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SMIM27 as an antibody target. Whether an autoantibody or antibody against SMIM27 could matter depends on whether native SMIM27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SMIM27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SMIM27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...