Seroatlas · Human Serome Atlas

SMIM24

Small integral membrane protein 24

Also known as: C19orf77, HSPC323, SIM24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75264
Gene
SMIM24
Ensembl
ENSG00000095932
Chromosome
19
Canonical length
130 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>O75264|SMIM24
     1  METLGALLVL EFLLLSPVEA QQATEHRLKP WLVGLAAVVG FLFIVYLVLL ANRLWCSKAR
    61  AEDEEETTFR MESNLYQDQS EDKREKKEAK EKEEKRKKEK KTAKEGESNL GLDLEEKEPG
   121  DHERAKSTVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
1,491 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 1,491 nTPM
  • kidney: 786 nTPM
  • duodenum: 708 nTPM
  • small intestine: 591 nTPM
  • stomach: 141 nTPM
  • bone marrow: 86 nTPM

Single-cell type

  • enterocytes: 3,850 nCPM
  • epididymal principal cells: 2,513 nCPM
  • epididymal efferent duct absorptive cells: 1,016 nCPM
  • epididymal clear cells: 423 nCPM
  • gastric chief cells: 358 nCPM
  • foveolar cells: 267 nCPM

Immune cell

  • NK-cell: 5.9 nTPM
  • memory B-cell: 2.6 nTPM
  • basophil: 1.9 nTPM
  • T-reg: 1.6 nTPM
  • plasmacytoid DC: 1.5 nTPM
  • naive CD8 T-cell: 1.1 nTPM

Brain region

  • cerebral cortex: 4 nTPM
  • choroid plexus: 3.9 nTPM
  • basal ganglia: 2.2 nTPM
  • hypothalamus: 2.2 nTPM
  • midbrain: 2.2 nTPM
  • white matter: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0.07
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM24 as an antibody target. Whether an autoantibody or antibody against SMIM24 could matter depends on whether native SMIM24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM24. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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