Seroatlas · Human Serome Atlas

SMIM2

Small integral membrane protein 2

Also known as: C13orf44, MGC5590, SMIM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVW6
Gene
SMIM2
Ensembl
ENSG00000139656
Chromosome
13
Canonical length
85 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>Q9BVW6|SMIM2
     1  MEAGERIDAS QLPHRVLETR GHAISILFGF WTSFICDTYI VLAWISKIKG SPDVSASSDE
    61  PYARIQQSRR QCHAEEDQSQ VPEAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • testis: 23 nTPM
  • thymus: 4.6 nTPM
  • epididymis: 2.7 nTPM
  • small intestine: 1.7 nTPM
  • heart muscle: 0.9 nTPM
  • skeletal muscle: 0.9 nTPM

Single-cell type

  • early spermatids: 53 nCPM
  • late primary spermatocytes: 47 nCPM
  • late spermatids: 6.6 nCPM
  • thymic myoid cells: 4.1 nCPM
  • proximal tubule cells: 1.8 nCPM
  • cardiomyocytes: 1.4 nCPM

Immune cell

  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 3 nTPM
  • basal ganglia: 2.5 nTPM
  • midbrain: 2.5 nTPM
  • amygdala: 2.3 nTPM
  • white matter: 2.1 nTPM
  • hypothalamus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0.04
gnomAD missense Z
0.91
DepMap mean gene effect
0.07
DepMap dependency class
none

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM2 as an antibody target. Whether an autoantibody or antibody against SMIM2 could matter depends on whether native SMIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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