Seroatlas · Human Serome Atlas

SMIM19

Small integral membrane protein 19

Also known as: C8orf40, SMI19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96E16
Gene
SMIM19
Ensembl
ENSG00000176209
Chromosome
8
Canonical length
107 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>Q96E16|SMIM19
     1  MAGGYGVMGD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRRI MRIFSVPPTE
    61  ETLSEPNFYD TISKIRLRQQ LEMYSISRKY DYQQPQNQAD SVQLSLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • liver: 128 nTPM
  • skeletal muscle: 114 nTPM
  • epididymis: 76 nTPM
  • kidney: 72 nTPM
  • tongue: 69 nTPM
  • thyroid gland: 69 nTPM

Single-cell type

  • fallopian tube ciliated cells: 264 nCPM
  • late primary spermatocytes: 251 nCPM
  • hepatocytes: 190 nCPM
  • respiratory ciliated cells: 182 nCPM
  • parietal cells: 179 nCPM
  • epididymal principal cells: 176 nCPM

Immune cell

  • plasmacytoid DC: 108 nTPM
  • basophil: 93 nTPM
  • NK-cell: 81 nTPM
  • T-reg: 79 nTPM
  • memory B-cell: 72 nTPM
  • naive B-cell: 69 nTPM

Brain region

  • white matter: 23 nTPM
  • hypothalamus: 20 nTPM
  • cerebral cortex: 20 nTPM
  • choroid plexus: 20 nTPM
  • spinal cord: 20 nTPM
  • cerebellum: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0.34
gnomAD missense Z
0.11
DepMap mean gene effect
0.22
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small integral membrane protein 19
  • Uncharacterised protein family UPF0697

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM19 as an antibody target. Whether an autoantibody or antibody against SMIM19 could matter depends on whether native SMIM19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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