Seroatlas · Human Serome Atlas

SMIM17

Small integral membrane protein 17

Also known as: SIM17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DL12
Gene
SMIM17
Ensembl
ENSG00000268182
Chromosome
19
Canonical length
118 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P0DL12|SMIM17
     1  MQSLRPEQTR GLLEPERTKT LLPRESRAWE KPPHPACTKD WEAVEVGASS HDSDEKDLSS
    61  QETGLSQEWS SVEEDDESEG SQGFVEWSKA PQQTTIVLVV CVLFLFLVLT GMPMMFHI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 13 nTPM
  • cerebral cortex: 8.6 nTPM
  • hippocampal formation: 6.5 nTPM
  • amygdala: 5.4 nTPM
  • midbrain: 5.2 nTPM
  • cerebellum: 4.4 nTPM

Single-cell type

  • podocytes: 3.4 nCPM
  • proximal tubule cells: 2.1 nCPM
  • distal convoluted tubule cells: 1.9 nCPM
  • renal connecting tubule cells: 1.6 nCPM
  • renal collecting duct intercalated cells: 1.5 nCPM
  • loop of henle epithelial cells: 1.2 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 24 nTPM
  • hypothalamus: 23 nTPM
  • pons: 23 nTPM
  • medulla oblongata: 20 nTPM
  • midbrain: 20 nTPM
  • hippocampal formation: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0.01
gnomAD missense Z
0.37
DepMap mean gene effect
-0.03
DepMap dependency class
selective

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM17 as an antibody target. Whether an autoantibody or antibody against SMIM17 could matter depends on whether native SMIM17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...