Seroatlas · Human Serome Atlas

SMIM15

Small integral membrane protein 15

Also known as: C5orf43, DKFZP686E2158, SIM15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z3B0
Gene
SMIM15
Ensembl
ENSG00000188725
Chromosome
5
Canonical length
74 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

74 residues, UniProt reviewed canonical sequence.

>Q7Z3B0|SMIM15
     1  MFDIKAWAEY VVEWAAKDPY GFLTTVILAL TPLFLASAVL SWKLAKMIEA REKEQKKKQK
    61  RQENIAKAKR LKKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • colon: 46 nTPM
  • stomach: 44 nTPM
  • liver: 40 nTPM
  • duodenum: 40 nTPM
  • rectum: 39 nTPM
  • small intestine: 38 nTPM

Single-cell type

  • esophageal apical cells: 235 nCPM
  • esophageal suprabasal cells: 181 nCPM
  • parietal cells: 113 nCPM
  • esophageal basal cells: 111 nCPM
  • gastric chief cells: 92 nCPM
  • migrating cytotrophoblasts: 91 nCPM

Immune cell

  • intermediate monocyte: 71 nTPM
  • NK-cell: 59 nTPM
  • non-classical monocyte: 58 nTPM
  • classical monocyte: 57 nTPM
  • T-reg: 56 nTPM
  • myeloid DC: 52 nTPM

Brain region

  • white matter: 31 nTPM
  • spinal cord: 27 nTPM
  • hypothalamus: 26 nTPM
  • medulla oblongata: 25 nTPM
  • basal ganglia: 25 nTPM
  • cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.71
gnomAD pLI
0.16
gnomAD missense Z
0.27
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small integral membrane protein 15
  • Uncharacterised protein family UPF0542

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM15 as an antibody target. Whether an autoantibody or antibody against SMIM15 could matter depends on whether native SMIM15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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