Seroatlas · Human Serome Atlas

SMIM14

Small integral membrane protein 14

Also known as: C4orf34, FLJ13289, SIM14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96QK8
Gene
SMIM14
Ensembl
ENSG00000163683
Chromosome
4
Canonical length
99 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to act upstream of or within blastocyst hatching. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>Q96QK8|SMIM14
     1  MAEGGFDPCE CVCSHEHAMR RLINLLRQSQ SYCTDTECLQ ELPGPSGDNG ISVTMILVAW
    61  MVIALILFLL RPPNLRGSSL PGKPTSPHNG QDPPAPPVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
111 nTPM

Expression across tissuesHPA

Tissue

  • liver: 111 nTPM
  • stomach: 44 nTPM
  • adrenal gland: 43 nTPM
  • tonsil: 42 nTPM
  • colon: 39 nTPM
  • salivary gland: 38 nTPM

Single-cell type

  • hepatocytes: 771 nCPM
  • esophageal apical cells: 532 nCPM
  • goblet cells: 527 nCPM
  • epididymal principal cells: 419 nCPM
  • early spermatids: 387 nCPM
  • prostatic glandular cells: 381 nCPM

Immune cell

  • naive B-cell: 108 nTPM
  • memory B-cell: 104 nTPM
  • plasmacytoid DC: 100 nTPM
  • myeloid DC: 56 nTPM
  • basophil: 54 nTPM
  • classical monocyte: 53 nTPM

Brain region

  • white matter: 47 nTPM
  • hypothalamus: 45 nTPM
  • spinal cord: 44 nTPM
  • medulla oblongata: 43 nTPM
  • pons: 43 nTPM
  • thalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.79
gnomAD missense Z
0.97
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small integral membrane protein 14
  • Protein of unknown function (DUF2615)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM14 as an antibody target. Whether an autoantibody or antibody against SMIM14 could matter depends on whether native SMIM14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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