Seroatlas · Human Serome Atlas

SMIM12

Small integral membrane protein 12

Also known as: C1orf212, FLJ90372, SIM12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EX1
Gene
SMIM12
Ensembl
ENSG00000163866
Chromosome
1
Canonical length
92 aa
Protein class
Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>Q96EX1|SMIM12
     1  MWPVFWTVVR TYAPYVTFPV AFVVGAVGYH LEWFIRGKDP QPVEEEKSIS ERREDRKLDE
    61  LLGKDHTQVV SLKDKLEFAP KAVLNRNRPE KN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • liver: 81 nTPM
  • adrenal gland: 53 nTPM
  • blood vessel: 53 nTPM
  • skeletal muscle: 53 nTPM
  • heart muscle: 50 nTPM
  • choroid plexus: 49 nTPM

Single-cell type

  • pericytes: 187 nCPM
  • esophageal apical cells: 146 nCPM
  • esophageal suprabasal cells: 128 nCPM
  • vascular smooth muscle cells: 122 nCPM
  • early spermatids: 116 nCPM
  • hofbauer cells: 111 nCPM

Immune cell

  • eosinophil: 127 nTPM
  • basophil: 104 nTPM
  • total PBMC: 88 nTPM
  • myeloid DC: 86 nTPM
  • intermediate monocyte: 82 nTPM
  • MAIT T-cell: 78 nTPM

Brain region

  • hypothalamus: 44 nTPM
  • cerebral cortex: 42 nTPM
  • pons: 39 nTPM
  • midbrain: 38 nTPM
  • medulla oblongata: 37 nTPM
  • white matter: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0.57
gnomAD missense Z
1.2
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • UPF0767 family
  • UPF0767 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM12 as an antibody target. Whether an autoantibody or antibody against SMIM12 could matter depends on whether native SMIM12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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