Seroatlas · Human Serome Atlas

SMIM11

Small integral membrane protein 11

Also known as: C21orf51, FAM165B, SIM11_HUMAN, SMIM11A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P58511
Gene
SMIM11
Ensembl
ENSG00000205670
Chromosome
21
Canonical length
58 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Focal adhesion sites

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

58 residues, UniProt reviewed canonical sequence.

>P58511|SMIM11
     1  MNWKVLEHVP LLLYILAAKT LILCLTFAGV KMYQRKRLEA KQQKLEAERK KQSEKKDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 44 nTPM
  • skeletal muscle: 42 nTPM
  • choroid plexus: 41 nTPM
  • heart muscle: 32 nTPM
  • amygdala: 26 nTPM
  • spinal cord: 26 nTPM

Single-cell type

  • epididymal clear cells: 2 nCPM
  • parietal cells: 1.8 nCPM
  • bergmann glia: 1.6 nCPM
  • oligodendrocytes: 1.5 nCPM
  • astrocytes: 1.4 nCPM
  • oligodendrocyte progenitor cells: 1.4 nCPM

Immune cell

  • naive B-cell: 29 nTPM
  • T-reg: 29 nTPM
  • memory B-cell: 26 nTPM
  • naive CD4 T-cell: 24 nTPM
  • MAIT T-cell: 23 nTPM
  • memory CD8 T-cell: 23 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • white matter: 29 nTPM
  • hippocampal formation: 26 nTPM
  • basal ganglia: 25 nTPM
  • cerebral cortex: 25 nTPM
  • medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0.62
gnomAD missense Z
0.12
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small integral membrane protein 11
  • FAM165 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM11 as an antibody target. Whether an autoantibody or antibody against SMIM11 could matter depends on whether native SMIM11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...