Seroatlas · Human Serome Atlas

SMIM10L2A

Small integral membrane protein 10-like protein 2A

Also known as: LED, LINC00086, LINC0086, MGC39606, NCRNA00086, SIL2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMW4
Gene
SMIM10L2A
Ensembl
ENSG00000178947
Chromosome
X
Canonical length
78 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a highly conserved small protein that contains a conserved motif (DUF4560) and may function as an integral membrane protein. This transcript was also shown to associate with enhancer chromatin and therefore may also function as an RNA to regulate enhancers. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

78 residues, UniProt reviewed canonical sequence.

>P0DMW4|SMIM10L2A
     1  MAASAALSAA AAAAALSGLA VRLSRSAAAR GSYGAFCKGL TRTLLTFFDL AWRLRMNFPY
    61  FYIVASVMLN VRLQVRIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM10L2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 39 nTPM
  • hippocampal formation: 32 nTPM
  • hypothalamus: 32 nTPM
  • amygdala: 29 nTPM
  • adrenal gland: 29 nTPM
  • basal ganglia: 22 nTPM

Single-cell type

  • adrenal cortex cells: 37 nCPM
  • other brain neurons: 22 nCPM
  • adrenal medulla cells: 21 nCPM
  • brain inhibitory neurons: 11 nCPM
  • brain excitatory neurons: 9.9 nCPM
  • sertoli cells: 8.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 56 nTPM
  • pons: 41 nTPM
  • cerebral cortex: 40 nTPM
  • hippocampal formation: 36 nTPM
  • thalamus: 35 nTPM
  • basal ganglia: 34 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM10L2A as an antibody target. Whether an autoantibody or antibody against SMIM10L2A could matter depends on whether native SMIM10L2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM10L2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM10L2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM10L2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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